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1

Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus

Uwe Lendeckel, Marco Arndt, Carmen Wolke, Dirk Reinhold, Thilo Kähne, Siegfried Ansorge

Journal:

Journal of Ethnopharmacology

Year:

2002

Language:

english

File:

PDF, 123 KB

english, 2002

2

1H NMR conformational study on n-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure–activity relationships

Carmen Mrestani-Klaus, Annett Fengler, Wolfgang Brandt, Jürgen Faust, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge, Klaus Neubert

Journal:

Journal of Peptide Science

Year:

1998

Language:

english

File:

PDF, 164 KB

english, 1998

3

The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro

Ekkehard Schön, Sigbert Jahn, Stephan T. Kiessig, Hans-Ulrich Demuth, Klaus Neubert, Alfred Barth, Rüdiger von Baehr, Siegfried Ansorge

Journal:

European Journal of Immunology

Year:

1987

Language:

english

File:

PDF, 655 KB

english, 1987

4

Prenylated proteins and lymphocyte proliferation: Inhibition by d-limonene and related monoterpenes

Stefan Schulz, Frank Bühling, Siegfried Ansorge

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 767 KB

english, 1994

5

Identification of point mutations in the aminopeptidase N gene by SSCP analysis and sequencing

Uwe Lendeckel, Thomas Wex, Marco Arndt, Karin Frank, Astrid Franke, Siegfried Ansorge

Journal:

Year:

1998

Language:

english

File:

PDF, 378 KB

english, 1998

6

Inhibition of dipeptidyl peptidase IV (DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro- oligopeptides ascertained by capillary electrophoresis

Torsten Hoffmann, Dirk Reinhold, Thilo Kähne, Jürgen Faust, Klaus Neubert, Rainer Frank, Siegfried Ansorge

Journal:

Journal of Chromatography A

Year:

1995

Language:

english

File:

PDF, 513 KB

english, 1995

7

Functional role of CD26 on human B lymphocytes

Frank Bühling, Udo Junker, Dirk Reinhold, Klaus Neubert, Lothar Jäger, Siegfried Ansorge

Journal:

Immunology Letters

Year:

1995

Language:

english

File:

PDF, 471 KB

english, 1995

8

Enzymatic activity of DPIVCD26 is involved in PMA-induced hyperphosphorylation of p56lck

Thilo Kähne, Klaus Neubert, Siegfried Ansorge

Journal:

Immunology Letters

Year:

1995

Language:

english

File:

PDF, 491 KB

english, 1995

9

Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-β1 (TGF-β1) in stimulated mouse splenocytes and thymocytes

Dirk Reinhold, Ute Bank, Frank Bühling, Michael Täger, Ilona Born, Jürgen Faust, Klaus Neubert, Siegfried Ansorge

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 378 KB

english, 1997

10

Proteolytic signals from Magdeburg

Siegfried Ansorge, Jürgen Langner, Frank Bühling, Uwe Lendeckel

Journal:

Immunology Today

Year:

2000

Language:

english

File:

PDF, 131 KB

english, 2000

11

Immunobiology of zinc and zinc therapy

Dirk Reinhold, Siegfried Ansorge, Kurt Grüngreiff

Journal:

Immunology Today

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

12

HIV-1 Tat: immunosuppression via TGF-β1 induction

Dirk Reinhold, Sabine Wrenger, Thilo Kähne, Siegfried Ansorge

Journal:

Immunology Today

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

13

Disposable TSM-biosensor based on viscosity changes of the contacting medium

Setyawan P. Sakti, Ralf Lucklum, Peter Hauptmann, Frank Bühling, Siegfried Ansorge

Journal:

Biosensors and Bioelectronics

Year:

2001

Language:

english

File:

PDF, 363 KB

english, 2001

14

Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites

Susan Lorey, Angela Stöckel-Maschek, Jürgen Faust, Wolfgang Brandt, Beate Stiebitz, Mark D. Gorrell, Thilo Kähne, Carmen Mrestani-Klaus, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge, Klaus Neubert

Journal:

Year:

2003

Language:

english

File:

PDF, 380 KB

english, 2003

15

The role of dipeptidyl peptidase IV (DP IV, CD26) in T cell activation and multiple sclerosis

Dirk Reinhold, Thilo Kähne, Andreas Steinbrecher, Annegret Gerber, Vera Preller, Bettina Gornickel, Sabine Wrenger, Siegfried Ansorge, Stefan Brocke

Journal:

Signal Transduction

Year:

2005

Language:

english

File:

PDF, 159 KB

english, 2005

16

Determination of the Solution Conformation of HIV-1 Tat(1–9) Peptides by Means of Molecular Dynamics Simulations Considering NMR Data and Docking Studies into an Active Site Model of DP IV

Annett Fengler, Carmen Mrestani-Klaus, Dirk Reinhold, Sabine Wrenger, Siegfried Ansorge, Jürgen Faust, Klaus Neubert, Wolfgang Brandt

Journal:

Journal of Molecular Modeling

Year:

1998

Language:

english

File:

PDF, 407 KB

english, 1998

17

Increased concentrations of transforming growth factor β1 and β2 in the plasma of patients with glioblastoma

Thomas Schneider, Michael Sailer, Siegfried Ansorge, Raimund Firsching, Dirk Reinhold

Journal:

Journal of Neuro-Oncology

Year:

2006

Language:

english

File:

PDF, 184 KB

english, 2006

18

Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts

Lindenlaub, Petra, Gollnick, Harald P M, Thielitz, Anja, Vetter, Robert W, Schultze, Bianca, Wrenger, Sabine, Simeoni, Luca, Ansorge, Siegfried, Neubert, Klaus, Faust, Jürgen

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 2.33 MB

english, 2007

19

Dual Inhibition of Dipeptidyl Peptidase IV and Aminopeptidase N Suppresses Inflammatory Immune Responses

DIRK REINHOLD, ALIZA BITON, ALEXANDER GOIHL, STEFANIE PIEPER, UWE LENDECKEL, JÜRGEN FAUST, KLAUS NEUBERT, UTE BANK, MICHAEL TÄGER, SIEGFRIED ANSORGE, STEFAN BROCKE

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 174 KB

english, 2007

20

Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome

Hans-Gert Bernstein, Alicja Bukowska, Dieter Krell, Bernhard Bogerts, Siegfried Ansorge, Uwe Lendeckel

Journal:

Brain Cell Biology

Year:

2003

Language:

english

File:

PDF, 346 KB

english, 2003

21

Alterations in Structure and Cellular Localization of Molecular Forms of DP IV/CD26 during T Cell Activation

Thilo Kähne, Hendrik Kröning, Ute Thiel, Arthur Jochen Ulmer, Hans-Dieter Flad, Siegfried Ansorge

Journal:

Cellular Immunology

Year:

1996

Language:

english

File:

PDF, 372 KB

english, 1996

22

Early Phosphorylation Events Induced by DPIV/CD26-Specific Inhibitors

Thilo Kähne, Klaus Neubert, Jürgen Faust, Siegfried Ansorge

Journal:

Cellular Immunology

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

23

Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia

Hans-Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Renate Stauch, Sara Ten Have, Johann Steiner, Henrik Dobrowolny, Bernhard Bogerts

Journal:

Journal of Psychiatric Research

Year:

2009

Language:

english

File:

PDF, 709 KB

english, 2009

24

A detailed protocol for the measurement of TGF-β1 in human blood samples

Dirk Reinhold, Ute Bank, Frank Bühling, Udo Junker, Jörn Kekow, Erwin Schleicher, Siegfried Ansorge

Journal:

Journal of Immunological Methods

Year:

1997

Language:

english

File:

PDF, 87 KB

english, 1997

25

Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells

Matthew Cook, Frank Bühling, Siegfried Ansorge, Peter J Tatnell, John Kay

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2002

Language:

english

File:

PDF, 184 KB

english, 2002

26

Evidence of a defective thiol status of alveolar macrophages from COPD patients and smokers

Michael Täger, Andreas Piecyk, Thomas Köhnlein, Ute Thiel, Siegfried Ansorge, Tobias Welte

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 464 KB

english, 2000

27

Extracellular cysteines define ectopeptidase (APN, CD13) expression and function

Beate Firla, Marco Arndt, Karin Frank, Ute Thiel, Siegfried Ansorge, Michael Täger, Uwe Lendeckel

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 294 KB

english, 2002

28

Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy

Jörn Dietzmann, Ute Thiel, Siegfried Ansorge, Klaus Hinrich Neumann, Michael Tüger

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 290 KB

english, 2002

29

Metabolism of Insulin and Glucagon : Breakdown of Radioiodinated Insulin and Glucagon in Rat Liver Cell Fractions

Siegfried Ansorge, Peter Bohley, Heidrun Kirschke, Jürgen Langner, Horst Hanson

Journal:

Year:

1971

Language:

english

File:

PDF, 596 KB

english, 1971

30

Metabolism of Insulin and Glucagon : Glutathione-Insulin Transhydrogenase from Microsomes of Rat Liver

Siegfried Ansorge, Peter BOHLEY, Heidrun Kirschke, Jürgen LANGNER, Bernd Wiederanders, Horst HANSON

Journal:

Year:

1973

Language:

english

File:

PDF, 878 KB

english, 1973

31

The Suitability of Bovine-Lens Leucine Aminopeptidase for Sequence Analysis and Limited Hydrolysis of Polypeptides

Bernd Wiederanders, Jürgen Lasch, Heidrun Kirschke, Peter Bohley, Siegfried Ansorge, Horst Hanson

Journal:

Year:

1973

Language:

english

File:

PDF, 724 KB

english, 1973

32

Cathepsin L : A New Proteinase from Rat-Liver Lysosomes

Heidrun KIRSCHKE, Jürgen LANGER, Bernd WIEDERANDERS, Siegfried ANSORGE, Peter BOHLEY

Journal:

Year:

1977

Language:

english

File:

PDF, 807 KB

english, 1977

33

Perillic Acid Inhibits Ras/MAPkinase-Driven IL-2 Production in Human T Lymphocytes

Stefan Schulz, Dirk Reinhold, Harald Schmidt, Siegfried Ansorge, Volker Höllt

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 269 KB

english, 1997

34

Inhibition of Alanyl Aminopeptidase Induces MAP-Kinase p42/ERK2 in the Human T Cell Line KARPAS-299

Uwe Lendeckel, Thilo Kähne, Marco Arndt, Karin Frank, Siegfried Ansorge

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 1.26 MB

english, 1998

35

Inhibition of Alanyl-Aminopeptidase Suppresses the Activation-Dependent Induction of Glycogen Synthase Kinase-3β (GSK-3β) in Human T Cells

Uwe Lendeckel, Beate Scholz, Marco Arndt, Karin Frank, Antje Spiess, Huixiong Chen, Bernard P. Roques, Siegfried Ansorge

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 85 KB

english, 2000

36

Dipeptidyl Peptidase IV (DP IV/CD26) mRNA Expression in PWM-Stimulated T-Cells Is Suppressed by Specific DP IV Inhibition, an Effect Mediated by TGF-β1

Marco Arndt, Uwe Lendeckel, Antje Spiess, Jürgen Faust, Klaus Neubert, Dirk Reinhold, Siegfried Ansorge

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 112 KB

english, 2000

37

Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans

Bernhard Kolmerer, Jonathan Clayton, Vladimir Benes, Taylor Allen, Charles Ferguson, Kevin Leonard, Ursula Weber, Marika Knekt, Wilhelm Ansorge, Siegfried Labeit, Belinda Bullard

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.11 MB

english, 2000

38

Expression and Activity of Ectopeptidases in Fibrillating Human Atria

Uwe Lendeckel, Marco Arndt, Sabine Wrenger, Karen Nepple, Christof Huth, Siegfried Ansorge, Helmut U. Klein, Andreas Goette

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

39

The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells

Sabine Wrenger, Dirk Reinhold, Torsten Hoffmann, Margot Kraft, Rainer Frank, Jürgen Faust, Klaus Neubert, Siegfried Ansorge

Journal:

Year:

1996

Language:

english

File:

PDF, 451 KB

english, 1996

40

Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation

Anja Thielitz, A. Bukowska, C. Wolke, Robert Vetter, Uwe Lendeckel, Sabine Wrenger, Yuichi Hashimoto, Siegfried Ansorge, Harald Gollnick, Dirk Reinhold

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 388 KB

english, 2004

41

Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers

Caroline Schmidt-Lucke, Funmi Belgore, Dirk Reinhold, Siegfried Ansorge, Helmut U. Klein, J. André Schmidt-Lucke, Gregory Y.H. Lip

Journal:

International Journal of Cardiology

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

42

Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation

Dirk Reinhold, Aliza Biton, Stefanie Pieper, Uwe Lendeckel, Jürgen Faust, Klaus Neubert, Ute Bank, Michael Täger, Siegfried Ansorge, Stefan Brocke

Journal:

International Immunopharmacology

Year:

2006

Language:

english

File:

PDF, 428 KB

english, 2006

43

Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13) — A novel approach for the treatment of inflammatory bowel disease

Ute Bank, Anke Heimburg, Martin Helmuth, Sofia Stefin, Uwe Lendeckel, Dirk Reinhold, Jürgen Faust, Petra Fuchs, Bianca Sens, Klaus Neubert, Michael Täger, Siegfried Ansorge

Journal:

International Immunopharmacology

Year:

2006

Language:

english

File:

PDF, 436 KB

english, 2006

44

Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary

Hans-Gert Bernstein, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Theresia Ernst, Renate Stauch, Kurt Trübner, Johann Steiner, Henrik Dobrowolny, Bernhard Bogerts

Journal:

Journal of Chemical Neuroanatomy

Year:

2008

Language:

english

File:

PDF, 2.07 MB

english, 2008

45

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Christine E. Schneemilch, Annelore Ittenson, Siegfried Ansorge, Thomas Hachenberg, Ute Bank

Journal:

Journal of Clinical Anesthesia

Year:

2005

Language:

english

File:

PDF, 607 KB

english, 2005

46

A Putative Role for Cathepsin K in Degradation of AA and AL Amyloidosis

Christoph Röcken, Barbara Stix, Dieter Brömme, Siegfried Ansorge, Albert Roessner, Frank Bühling

Journal:

The American Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 3.08 MB

english, 2001

47

Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes

Dirk Reinhold, Robert W Vetter, Kati Mnich, Frank Bühling, Uwe Lendeckel, Ilona Born, Jürgen Faust, Klaus Neubert, Harald Gollnick, Siegfried Ansorge

Journal:

Year:

1998

Language:

english

File:

PDF, 146 KB

english, 1998

48

R-esp1, a rat homologue of Drosophila Groucho, is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells

Marco Arndt, Ute Bank, Karin Frank, Bernhard A. Sabel, Siegfried Ansorge, Uwe Lendeckel

Journal:

Year:

1999

Language:

english

File:

PDF, 218 KB

english, 1999

49

Intravenous immunoglobulins and transforming growth factor β

Jörn Kekow, Dirk Reinhold, Thomas Pap, Siegfried Ansorge

Journal:

Year:

1998

Language:

english

File:

PDF, 64 KB

english, 1998

50

Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones

Dirk Reinhold, Bernhard Hemmer, Bruno Gran, Ilona Born, Jürgen Faust, Klaus Neubert, Henry F McFarland, Roland Martin, Siegfried Ansorge

Journal:

Journal of Neuroimmunology

Year:

1998

Language:

english

File:

PDF, 347 KB

english, 1998